TARGETING THE UBIQUITIN SYSTEM BY FRAGMENT-BASED DRUG DISCOVERY

Targeting the ubiquitin system by fragment-based drug discovery

The ubiquitin system contains a wealth of potential drug targets for many diseases and conditions, including neurodegenerative, immune, metabolic and developmental diseases, as well as multiple cancers.Despite years of research, relatively few clinical inhibitors or specific chemical probes for SexFlesh proteins within the ubiquitin system exist, w

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A Dual-Frequency Faraday Laser

The Faraday laser, with Faraday anomalous dispersion optical filter (FADOF) as frequency-selection element, is a natural narrow-bandwidth light source for laser physic experiments.In this work, a dual-frequency (DF) Faraday laser is demonstrated for the first time on Cs D2 line at 852 nm.The frequencies of the two modes of DF Faraday laser hinge on

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